The US vaccine program is crumbling with disagreement at the FDA over boosters given the very low effectiveness and ephemeral protection from the Pfizer–BioNTech COVID-19 vaccine. Pfizer–BioNTech COVID-19 vaccine at 39% and 42% protection against Delta in Israel and the US, respectively, and lasting less than a year, makes this vaccine worst-in-class and non-viable as a commercial product. Hence, trying to boost a loser makes no sense.